Resource Type

Journal Article 1119

Conference Videos 140

Conference Information 8

Year

2024 2

2023 170

2022 189

2021 276

2020 118

2019 45

2018 28

2017 52

2016 33

2015 35

2014 46

2013 42

2012 23

2011 24

2010 44

2009 30

2008 23

2007 36

2006 3

2005 2

open ︾

Keywords

SARS-CoV-2 33

COVID-19 25

CO2 capture 19

2 18

TiO2 14

CO2 9

1 8

Photocatalysis 8

photocatalysis 8

CO2 emissions 7

Deep learning 7

Al2O3 6

Reinforcement learning 6

microwave scatterometer 5

China 4

H2S 4

MnO2 4

N2O 4

biomass 4

open ︾

Search scope:

排序： Display mode:

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 969-974 doi: 10.1007/s11684-021-0912-z

Abstract: A cross-sectional study was conducted among 2–10-year-old children in Sokoto, in August and December2016, to determine the endemicity of malaria based on Plasmodium falciparum prevalence rate (PfPR2-10-10) and to describe the disease pattern.was higher than expected (2.6%), considering the endemicity pattern which was mesoendemic based on a PfPR2-10-10 of 34.8%.

Keywords： severe malaria     nigeria     malaria mortality     PfPR2-10     intermediate malaria transmission    

HTML PDF Collect

Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 2,   Pages 109-109 doi: 10.1007/s11705-009-0258-6

HTML PDF Collect

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract:

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusiontranscripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remainedS100A10 subunit, although S100A10 transcripts remained constitutive.Antibodies against ANXA2, S100A10, or combination of both all remarkably inhibited the IRPG and invasivenessS100A10.

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

HTML PDF Collect

NO hydrogenation to NH over FeCu/TiO catalyst with improved activity

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1973-1985 doi: 10.1007/s11705-023-2364-2

Abstract: Notably, the optimized 10Fe-8Cu/TiO2 catalyst exhibited exceptional catalytic performance

Keywords： NO hydrogenation     synthetic ammonia     10Fe-xCu/TiO2     high selectivity    

HTML PDF Collect

PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 6, doi: 10.1007/s11783-017-0966-y

Abstract: The PM in the submicron mode for burning with raw coal contributes to 33%±10 % of PM emissions, much

Keywords： coal-fired chain-grate boiler     PM10     size distribution     particulate emission control devices    

HTML PDF Collect

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chainBased on the common axoneme structure of motile cilia and sperm flagella, DNAH10 variants areUsing exome sequencing, we identified a novel DNAH10 homozygous variant (c.589C > T, p.R197W), and transmission electron microscopy revealed strikingly disordered axoneme 9+2 architecture and innerSubsequently, animal models of Dnah10-knockin mice harboring missense variants and Dnah10

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

HTML PDF Collect

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitspublic databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCIn 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patientsMoreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

HTML PDF Collect

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Frontiers in Energy 2023, Volume 17, Issue 1,   Pages 1-4 doi: 10.1007/s11708-023-0869-5

Abstract: . {{custom_ra.content}} . . . {{article.highlightEn}} . . . {{article.abstractEn}} . . . {{article.authorSummayEn}} .
HTML PDF Collect

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: In this study the effects of lipopolysaccharide (LPS) and interleukin-10 (IL-10) on the formation ofThe cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.However, the significant elevation by LPS was abrogated when IL-10 was added.IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.The inhibitive effect of IL-10 is an important factor for delaying atherosclerosis processes.

Keywords： inflammatory     presence     interleukin-10     dose-dependent     ox-LDL    

HTML PDF Collect

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

HTML PDF Collect

A Geodesign Method of Human-Energy-Water Interactive Systems for Urban Infrastructure Design: 10KM2 Near-Zero District Project in Shanghai Article

Perry Pei-Ju Yang, Cheryl Shu-Fang Chi, Yihan Wu, Steven Jige Quan

Engineering 2018, Volume 4, Issue 2,   Pages 182-189 doi: 10.1016/j.eng.2018.03.014

Abstract:

The grand challenges of climate change demand a new paradigm of urban design that takes the performance of urban systems into account, such as energy and water efficiency. Traditional urban design methods focus on the form-making process and lack performance dimensions. Geodesign is an emerging approach that emphasizes the links between systems thinking, digital technology, and geographic context. This paper presents the research results of the first phase of a larger research collaboration and proposes an extended geodesign method for a district-scale urban design to integrate systems of renewable energy production, energy consumption, and storm water management, as well as a measurement of human experiences in cities. The method incorporates geographic information system (GIS), parametric modeling techniques, and multidisciplinary design optimization (MDO) tools that enable collaborative design decision-making. The method is tested and refined in a test case with the objective of designing a near-zero-energy urban district. Our final method has three characteristics.①Integrated geodesign and parametric design: It uses a parametric design approach to generate focal-scale district prototypes by means of a custom procedural algorithm, and applies geodesign to evaluate the performances of design proposals. ② A focus on design flow: It elaborates how to define problems, what information is selected, and what criteria are used in making design decisions.③Multi-objective optimization: The test case produces indicators from performance modeling and derives principles through a multi-objective computational experiment to inform how the design can be improved. This paper concludes with issues and next steps in modeling urban design and infrastructure systems based on MDO tools.

Keywords： Geodesign     Urban design     Urban infrastructure     Energy performance     Iterative process     Multi-objective optimization    

HTML PDF Collect

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract:

In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic polymorphism    

HTML PDF Collect

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: gene is thought to be a tumor-suppressor gene. Our previous study found that overexpression of gene in PC3 cell line could slow down the tumor proliferation rate, associated with a mild decrease in expression. The decrease could increase the sensitivity of radiotherapy to tumors. Thus, we supposed to have an “enhanced firepower” effect by combining overexpressed gene therapy and I radiation therapy uptake by overexpressed hNIS protein. We found a weak endogenous expression of hNIS protein in PC3 cells and demonstrated that the low expression of hNIS protein in PC3 cells might be the reason for the low iodine uptake. By overexpressing in PC3, the radioactive iodine uptake ability was significantly increased. Results of and tumor proliferation experiments and F-fluorothymidine ( F-FLT) micro-positron emission tomography/computed tomography (micro-PET/CT) imaging showed that the combined gene therapy and I radiation therapy mediated by overexpressed hNIS protein had the best tumor proliferative inhibition effect. Immunohistochemistry showed an obvious decrease of expression and the lowest expression. These data suggest that via inhibition of expression, overexpressed might enhance the effect of radiation therapy of I uptake in overexpressed PC3 cells.

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter    

HTML PDF Collect

Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus Article

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Engineering 2023, Volume 28, Issue 9,   Pages 206-221 doi: 10.1016/j.eng.2023.03.006

Abstract: indispensable specific cellular receptor for α-toxin (Hla), a-disintegrin and metalloproteinase 10(ADAM10) is exploited to accelerate S. aureus infection through diverse mechanisms.The extraordinary contribution of ADAM10 to S. aureus pathogenesis renders it an attractiveOur study is the first to demonstrate the indispensable role of ADAM10 in S. aureus-inducednecroptosis, and it enhances our knowledge of the role of ADAM10 in S. aureus infection.

Keywords： Host-directed therapy     Kaempferol     ADAM10 inhibitor     Staphylococcus aureus infection     Barrier disruption    

HTML PDF Collect

Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey

Zhiping Yang, Qiong Wu, Kaichun Wu, Daiming Fan

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 94-99 doi: 10.1007/s11684-012-0181-y

Abstract:

Systematic reviews and meta-analyses are playing an increasingly important role in clinical research and practice. This study aimed to measure the scientific production of systematic review and meta-analysis from the three major regions of China: the Mainland (ML), Hong Kong (HK), and Taiwan (TW). English articles on systematic review and meta-analysis from ML, HK, and TW from 2001 to 2010 were retrieved from the PubMed database. The total number of articles, impact factors (IF), and articles published in high-impact journals were conducted for quantity and quality comparisons among the three regions. There were 1 587 published articles from ML (1 292), HK (203), and TW (92) during the past ten years. The annual total numbers of articles in the three regions increased significantly from 2001 to 2010 (from 13 to 677). The number of articles from ML has exceeded that from TW since 2001, and surpassed that from HK in 2003. The accumulated IF of articles from ML (3 488.24) was higher than those from HK (493.16) and TW (216.39). HK had the highest average IF of 3.31, followed by ML of 2.90 and TW of 2.85. Researchers from HK published a larger proportion of papers in high-impact journals than those from ML and TW. The Cochrane Database of Systematic Reviews was the most popular journal in China. Chinese authors have been very active to enhance the systematic review and meta-analysis research over the past ten years, especially in ML. The gap between ML and the other two regions has been narrowed. But there is still considerable room for Chinese authors to improve their studies on systematic review and meta-analysis.

Keywords： systematic review     meta-analysis     China     Chinese     impact factor    

HTML PDF Collect

Title Author Date Type Operation

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Journal Article

Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Journal Article

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

NO hydrogenation to NH over FeCu/TiO catalyst with improved activity

Journal Article

PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Journal Article

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

A Geodesign Method of Human-Energy-Water Interactive Systems for Urban Infrastructure Design: 10KM2 Near-Zero District Project in Shanghai

Perry Pei-Ju Yang, Cheryl Shu-Fang Chi, Yihan Wu, Steven Jige Quan

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Journal Article

Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey

Zhiping Yang, Qiong Wu, Kaichun Wu, Daiming Fan

Journal Article